The Final Plague begins in Lehigh Iowa on May 4, 2012. As someone who hates any kind or rodent, this was not a good comic for me to read. It begins when a small farming family finds that their home has become infested by rats. Helen is tough as nails and ends up killing the first one after a battle on her front porch. Helen is forced to use a shovel to decapitate it and even then, the damn thing still twitches.
The second rat attack happens in New York City on the same date. A homeless man is drunk in an alley when he is attacked by what can only be described as a horde of rats. There are so many rats, they quickly overpower the drunk and consume his alive.
The third incident happens on the same date in a lab in New Jersey. Jeremy is working with the rats and he notices that some of them have bloodshot eyes and assumes they are blind. Because he believes the rats to be sick but not contagious, Jeremy does not follow along with proper quarantine protocols, much to the disgust of fellow scientist Carol. Of course it's not Jeremy is hurt but a fellow when the rat sprays blood at her which lands in her mouth. Finally, it's decided that the rats need to go into quarantine and be dissected so that the scientists can figure out exactly what the hell is wrong with them.
The one thing that is certain is that rats aren't acting the way that rats are supposed to. Normally, a rat would shy away from a human being if it encountered them but these rats are bold enough to actively attack humans when they come into contact with them. We later learn that it's not just the rats and that in fact all of the furry rodents are doing damage to humans when they encounter them. The red eyes suggest some sort of infection which is making the rodents more aggressive than usual. Alan, the exterminator posits that all of the pesticides that humanity has been using has emboldened the rats and changed their behaviour. Of course, Alan finds out the hard way when he succumbs to the rats when he tries to exterminate them at the farm.
The Final Plague Vol I quickly establishes the idea that rodents aren't behaving normally and are attacking and consuming humans. As someone with a deep fear of rodents this comic rises to the level of horror for me. It does however make historic sense. We know for instance hat the bubonic plague was carried by fleas on rats which is estimated to have killed 50 million people. Rodents are nothing to joke about because they carry disease, so the idea that the end of humanity might come at the paws of rodents makes perfect sense. It's particularly true in a city like New York city, where the rat population is enormous. Think about what it would mean for humanity if the rats suddenly started working in a swarm to attack humans. And since they can slip into a hole as big as a quarter and quickly reproduce, this would be a true nightmare because not only have to deal with the diseases which rats carry, we'd be attacked as prey.