It's the year 2015, and Cassandra has a gun pointed at Cole. Cole suddenly yells do it and Cassandra jumps but complies by pulling the trigger. Cole tells her that she cannot hesitate and seems completely frustrated, telling Cassandra that she has to do it again until she get it right. Cassandra talks about how her father would be so proud because he worked three jobs to send his daughter to medical school and here she is learning how to kill. Cole points out that if the guy who killed Jeremy shows up again the hard part will be over - knowing that the trigger is being pulled for the right reason. This time, Cassandra is able to pull the trigger without hesitation, causing Cole suggest they move onto to live rounds. They are interrupted by Chinese food delivery. Cole and Cassandra talk about how long it might take for the 12 monkeys to break Jennifer.
Cassandra is now at the police station and being questioned about discharging a patient from the hospital. Detective Roll brings up Jennifer and Cassandra admits that she saw the man who took her. Roll states that Jennifer is considered very dangerous because she killed her co-workers a few years ago. Roll pulls out a picture of Jennifer and points to a Black scientist who managed to escape the murder spree; however, the man is missing. Roll then shows Cassandra a picture of Cole claiming that he might be involved. Cassandra then fakes getting a call and uses her phone to take a picture of the missing scientist.
Later, in the car, Cassandra shows Cole the picture of the missing scientist - Dr. Henri Toussaint, claiming that they met in Haiti, a year after Cole kidnapped her. We get a flash of Cassandra working with Toussaint in Haiti during an outbreak. Cassandra pulls up to the CDC building saying that it's not everyday one sees the building you destined to die in.
Inside the CDC, Cassandra is told that she is welcome back, though she was a little off the rails in Haiti. Cassandra makes it clear to Jules that she is not there for a job. Cassandra claims that she needs some help on tropical infections and asks if Henri could help, only to be informed that Henri was shot dead by gangs apparently
Cole is determined to talk to Henri before he dies, saying that he can travel back to 2014 and make Henri tell him about the night before he dies. Cassandra questions if there is another way but Cole believes that if they waste time, Jennifer could crack and the 12 Monkeys could find the virus. Cassandra asks who Cole will find Henri and Cole suggests she tell him. Cassandra asserts that Haiti is dangerous and there were gangs who stole their medicine. Cassandra adds that she sent Henri out to get more drugs and it got out of control Cole tells Cassandra that it will be okay, but Cassandra is adamant that it will not and points out that Cole will see her there. Cassandra tells Cole to do her a favour and stay away from her while she is in Haiti.
Cole returns back to 2043 and Jones immediately asks for an update, so Cole explains that he needs to go back to Haiti in 2014. The scientist sargue about sending Cole back to 1987, or to see Leeland before his brains are blown out, or even before Jennifer is taken. With the exception of 1987, this is all risky because Cole could run into a version of himself. A frustrated Cole walks away and joins Ramse, leaving the scientists to argue. Ramse and Cole discuss scavengers. Jones joins Cole and Ramse and announces that it has been decided that Cole will be headed to Haiti but warns that Cassandra cannot see him and that there is an issue with solar flares.
In Washington D.C. in 2014, Cassandra informs Aaron that she is headed to Haiti. Cassandra argues that people are dead and no one knows what it is. Aaron is not convinced and suggests that Cassandra is chasing after outbreaks because her kidnapper told her that a virus is going to wipe out the planet. Aaron asks Cassandra when she is coming home and she replies that she doesn't know. Aaron asks if Cassandra is going to show up at the hotel a year from now to find her kidnapper, adding that the world is not going to end.
Cassandra is now in Haiti with the CDC. Cassandra makes her way into the containment zone and only pauses long enough to grab some gloves. Cassandra grabs a patient but is intercepted by Jules (who btw pulls down his face mask) Jules points out Henri, saying that they are lucky to have a local guy. An angry man bursts in with a gun and demands a bed for a sick child. Cassandra talks the man down and hands the child to Henri. The man leaves and Cassandra is concerned that if the man who dropped the child off was infected, they just sent more infection to the outside world. Cassandra calls for the isolation of the tents. Jules instead orders the doctors to get some rest so they can start fresh in the morning. Cassandra however heads to her tent and starts doing research.
Later, Cassandra heads outside and runs into Henri, who is drinking and so invites him back to her room. They share a drink and talk about the encounter with the man who had the gun. Cassandra brings up infections and how Henri must be used to that kind of thing living here. Henri talks about his sister dying of measles when he was child and how he believed that if he were a doctor, he would have a power, but now he knows that nature cannot be controlled - it only bends. Henri questions what virus they are dealing with and Cassandra replies that it is something they should not under estimate.
Cole arrives in Haiti just outside the containment camp.